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Just one troponin assay ought to be applied offered the heterogeneity of assays. This is particularly significant for multicentre trials.
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While using the newer assay, troponin will be detected at decreased limits of detection, as proven via the strong part of the blue curve in the ideal panel. The 99th percentile documented for your more recent TnT assay is actually similar to to the older assay, suggesting the presumed form on the distribution curves for the two assays is analogous, as shown schematically in the figure.
The higher Bogus optimistic price for troponin tests is basically on account of indiscriminate ordering tactics, that has produced an issue known topanwin slot as spectrum bias
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